ABSTRACT
This study was conducted to review the efficacy of different sources of stem cells in bone regeneration of cleft palate patients. The majority of previous studies focused on the transplantation of bone marrow mesenchymal stem cells. However, other sources of stem cells have also gained considerable attention, and dental stem cells have shown especially favorable outcomes. Additionally, approaches that apply the co-culture and co-transplantation of stem cells have shown promising results. The use of different types of stem cells, based on their accessibility and efficacy in bone regeneration, is a promising method in cleft palate bone regeneration. In this regard, dental stem cells may be an ideal choice due to their efficacy and accessibility. In conclusion, stem cells, despite the lengthy procedures required for culture and preparation, are a suitable alternative to conventional bone grafting techniques.
ABSTRACT
Statement of the Problem: The rate of antibiotic resistance in bacteria and side effects of antibiotics and oral and teeth health care products are increasing. Therefore, researchers aim at finding new alternatives to control bacteria of den-tal caries
Purpose: The objective of this study was to investigate the inhibitory and bacte-ricidal effects of different concentrations of zinc sulfate and zinc acetate solu-tions on the main recognized agent of dental caries, Streptococcus mutans
Materials and Method: In this experimental study, different concentrations of aqueous zinc sulfate and zinc acetate solutions were prepared and the minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] of these salts for Streptococcus mutans were determined in compare with penicil-lin, chlorhexidine by micro-serial dilution method. In addition, the diameters of zone of inhibition for these salt solutions in four concentrations along with chlor-hexidine, as the control, were detected by the disc diffusion method
Results: MIC and MBC of zinc sulfate solution were higher than penicillin and chlorhexidine. There were not statistically significant differences between the MIC and MBC of zinc acetate solution, penicillin, and chlorhexidine. In 25 and 50 Mug/mL concentrations, the diameters of inhibition zone for zinc sulfate were more than zinc ac
Conclusion: Zinc sulfate and zinc acetate salts with 37.19 and 31.25 Mugr/mL concentration had inhibitory effect on Streptococcus mutans growth respectively, although, no priority in antibacterial activity of the studied zinc salts was deter-mined in comparison with penicillin and chlorhexidine